jet

jet @hackertalks.com 4mo ago

Funnily enough open-ai goes into nanny mode after this question is asked and will refuse to do some math or answer other questions that MIGHT be related to the initial question.

The big joke:

Maybe 100 cups of coffee is lethal to a 50kg adult 50/50 chance if you trust the MSDS, but the 50L of liquid you have to drink to take 100 cups of coffee is 100% lethal... none of these LLM agents pointed that out.

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jet @hackertalks.com 4mo ago

As a long time user of BSD laptops (apple) I've never had one surprise me when the screen was closed. FWIW I never buy these bsd laptops, they are given to me by $current.employer for work.

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jet @hackertalks.com 4mo ago

Graceful like closing a laptop and putting it in a backpack only to have windows refuse to shutdown and become a heater until it cooks the battery and ruins the screen....

jet @hackertalks.com 4mo ago

they eat too much and do too little. There is only a crisis of gluttony and sloth.

Allow me to introduce you to the insulin model of obesity: https://hackertalks.com/post/13737743

CICO / Eat Less Move More - Would say that the type of food doesn't matter, but in animals adding insulin without changing the diet causes weight gain! This disproves the simplistic CICO advice of weight loss.

jet @hackertalks.com 4mo ago

Do you know if there’s something like this chart, but for food instead of supplements? https://informationisbeautiful.net/visualizations/snake-oil-scientific-evidence-for-nutritional-supplements-vizsweet/

Right so the coffee heart disease link makes huge assumptions - i.e. that everyone is in the same metabolic context (i.e. standard western diet). From my reading there is a reasonable probability that for someone eating the standard western diet, small doses of coffee have a cardiovascular benefit... but someone with a healthy metabolism (ketogenic metabolism) wouldn't see any of those same benefits (low cardio vascular disk to begin with). Whenever you see this type of "good for you" advice, you need to ask

According to whom
On the basis of what
In what context?

I’ve seen that seed oils are bad. I’ve also seen people that say all oil is bad, and (without having looked into this at all), it seems like the “all oil is bad” people are probably overreacting and it’s something more specific like seed oils or something like that (though what specifically about them is bad?). It’d be nice to see a chart like above with handy links to scientific papers.

The question shouldn't be "why seed oils are bad" (they are), but rather "Why replace saturated fat with something that didn't exist until 115 years ago?". We don't know for certain why seed oils are bad, the best theory I've seen to explain it is that plant sterols are close enough to animal sterols that they go throughout the body to the cholesterol sites, but then interfere with cholesterol signaling (i.e. https://hackertalks.com/post/4924264)

Here are some papers to get you started on why seed oils arnt great for you:

https://hackertalks.com/post/6200879 paper - https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.127.4
charts showing seed oils increased all cause mortality
https://hackertalks.com/post/6054186 - https://doi.org/10.1136/bmj.i1246
https://hackertalks.com/post/11881867 - http://dx.doi.org/10.3389/fnut.2021.748847

https://www.scientificamerican.com/podcast/episode/are-seed-oils-bad-for-you-debunking-a-viral-social-media-myth/

This doesn't cite any sources... it's just a dude giving their opinion.

Diet doctor has a great medical staff and writes extremely well cited reviews the literature and doesn't say anything that they can't support, so for the full seed oil story please read: https://www.dietdoctor.com/low-carb/vegetable-oils#conclusion

TLDR: "If your goals include eating less processed food — as ours do — the best course may be to avoid these newcomers and return to traditional dietary fat sources. Get your fats from whole foods, including avocados, oily fish, nuts, seeds, olive oil, traditional oils, butter, coconut oil and meats."

Highly oxidized
High omega-6/omega-3 ratio
Plant sterols interfere with healthy cholesterol functioning

If someone is struggling with metabolic health and is thinking about taking the drugs I think carbohydrates are the most effective leaver they can pull, seed oils will help - but not nearly as much.

2

jet @hackertalks.com 4mo ago

Probably not by itself. The latest US attempt to modify dietary guidance became a political firestorm. Making health a divisive wedge issue... I'm not hopeful the US will move away from processed foods in the foreseeable future.

The problem is that people have tied their identity to "correct foods", and with so much ferocious and conflicting advice given most people in the middle have given up

I'll list what I consider the principles of healthy food (remember based on whole foods), and you will see how controversial it can be

Saturated fats are not unhealthy
Industrial seed oils (vegetable oils) that from from chemical plants are not healthy
Processed plant based foods are not healthy (because of the above)
Animal sourced foods are the most nutritious and healthy
Pesticides in the grain supply have a as-yet-unrealized health impact , but it seems large
Some people can tolerate some plants, but not all people can tolerate all plants (i.e. gluten, wheat, etc)

The standard western diet is so bad anything looks good compared to it, but that means lay people just see people in the plant based, keto, animal based camps giving conflicting advice. Nutritional science is laughable at the moment, not much in the way of falsifiable experiments being done.

From my reading Metabolic dysfunction is rooted in a highly processed food, highly carbohydrate based, and rich in processed seed oil diet.. Removing any one of these might be enough to swing someone back into metabolic health, but for people taking the drugs they probably need to change all three.

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jet @hackertalks.com 4mo ago

The SLGT2 inhibitor/GLP1 agonists do not solve the core problem of metabolic disease. They do help people in the short term, but without addressing WHY people are metabolically unhealthy we wont get out of the current metabolic crisis.

Without dietary changes: People will cycle on and off the drugs, losing bone and muscle mass each cycle, still ending up with non-communicable diseases. Will their lived experiences be better then without the drugs? Yes, probably - but there are real costs and side-effects to be calculated. This will also hurt the processed food industries profits, so they will have to find a new way to keep people addicted during a drug cycle. However, it is a new drug that will make some pharmacological concerns very rich... so there is that.

The secret to metabolic health is getting rid of standard western processed foods (i.e. whole foods only, nothing from a factory, plastic bag, or box).

TLDR: Weight as a subscription service isn't healthy for a society at large (heh).

jet @hackertalks.com 4mo ago

its really gratifying to see metabolic health getting into normal general practice.

jet @hackertalks.com 4mo ago

I think this is the position statement she was referring to half way through the talk: https://www.diabetessociety.com.au/wp-content/uploads/2023/11/Managing-Type-2-Diabetes-with-Therapeutic-Carbohydrate-reduction-TCR-November-2023_Final.pdf

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jet @hackertalks.com 4mo ago

Are you a EE by chance? Not many people dig into domain transformers for fun ;)

jet @hackertalks.com 4mo ago

pychess.org has modified the dobutsu shogi piece set for western chess, bless their hearts.

https://github.com/LuffyKudo/Doubutsu-Chess

https://luffykudo.wordpress.com/2024/08/01/dobutsu-chess/

jet @hackertalks.com 4mo ago

I've acquired 4 sets of diagrammatic chess sets as of today! Western, japanese (x3)... i just need to find a sticker set for XongQi and I'll be all set.