I honestly considered it to be all in good fun. I know plenty of people who are Vegan for a variety of reasons and I love them all. In fact they laughed the most at this.
None. I just used the guide on iFixit but cloned the original drive with CloneZilla to make restoration easier. I did also buy a replacement EM shielding foil so I could leave the original one on the original drive.
While they do not specifically call it out it seems to help Fallout 4 run better (more stable). At least in my testing so far.